Angular Cheilitis Mouth Sores Explained | As Featured in Woman’s World

Have you experienced a sore in the corner of your mouth? It may be something known as angular cheilitis. Board-certified dermatologist, Dr. Mona Foad, expands upon her insights on this topic from her recent feature in Woman’s World.

What is angular cheilitis and what are the main causes?

Angular cheilitis is a condition that causes cracks or sores at the corners of the mouth, typically resulting in discomfort and irritation. The primary causes of angular cheilitis include fungal infections (especially Candida, a type of yeast) and bacterial infections, such as Streptococcus. These pathogens thrive in the moist environment around the mouth. Additionally, nutritional deficiencies—particularly in iron, zinc, and B vitamins like B2 (riboflavin) and B3 (niacin)—can contribute to the condition, as these nutrients are important for maintaining healthy skin. Moisture buildup, such as drooling during sleep, also plays a role in creating a favorable environment for these infections. While stress doesn’t directly cause angular cheilitis, it may exacerbate behaviors like lip licking or biting, which can worsen the condition. Seasonal changes, especially in colder months, can increase susceptibility due to drier skin, making it more prone to cracking.

Are there any features or preconditions that may make us more susceptible to angular cheilitis?

Certain factors may make individuals more prone to angular cheilitis. For example, those with deeper skin folds around the mouth—whether due to facial structure or age—are more likely to develop this condition. This is because the folds can trap moisture and promote infection. Individuals with a history of eczema or other conditions that compromise the skin barrier are also at higher risk. This is because their skin is already more vulnerable to irritation and infection. Those who wear dentures or experience excessive drooling during sleep may also be at increased risk.

In most cases, angular cheilitis is benign and can be treated with simple interventions like moisturizing creams. However, if the condition becomes recurrent or persistent, it may signal an underlying health issue, such as diabetes or immune system deficiencies. Consulting a healthcare provider is recommended if the condition doesn’t resolve with basic care.

Are perimenopausal or menopausal women more prone to angular cheilitis?

Perimenopausal and menopausal women may be more susceptible to angular cheilitis due to hormonal changes that lead to drier skin. As estrogen levels decline during menopause, the skin becomes thinner and less able to retain moisture. As a result, it is more prone to cracks and irritation. This is especially true in areas such as around the mouth. To manage this risk, it’s important to use hydrating skincare products. You should also ensure adequate intake of vitamins that support skin health including zinc, biotin, and B vitamins. Hormone replacement therapy (HRT) or other treatments designed to address menopause-related skin changes may also help. However, it’s always a good idea to consult with a healthcare provider for personalized recommendations.

How can you treat angular cheilitis?

Treating angular cheilitis involves addressing both the symptoms and underlying causes. Keeping the affected area moisturized is essential, and thick moisturizers, such as petroleum jelly or lanolin, work well to lock in moisture, particularly during sleep when saliva can pool in the corners of the mouth. If the condition is caused by a fungal or bacterial infection, topical antifungal or antibiotic creams may be necessary. You may need to get a prescription from your dermatologist or primary care physician.  If nutritional deficiencies are contributing, increasing intake of key nutrients—like zinc, iron, and B vitamins—can help support skin healing and prevent future flare-ups. To minimize moisture buildup, consider adjusting your sleeping position or using a protective balm before bed. If the condition persists or recurs frequently, consulting a dermatologist is recommended to rule out other potential causes and to receive more targeted treatment.